Resistance to trimethoprim and sulfonamides
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چکیده
منابع مشابه
Resistance to trimethoprim and sulfonamides.
Sulfonamides and trimethoprim have been used for many decades as efficient and inexpensive antibacterial agents for animals and man. Resistance to both has, however, spread extensively and rapidly. This is mainly due to the horizontal spread of resistance genes, expressing drug-insensitive variants of the target enzymes dihydropteroate synthase and dihydrofolate reductase, for sulfonamide and t...
متن کاملCharacterization of transferable plasmids from Shigella flexneri 2a that confer resistance to trimethoprim, streptomycin, and sulfonamides.
A set of plasmids conferring resistance to several antibiotics, including the combination of trimethoprim and sulfamethoxazole, has been isolated from Escherichia coli following conjugative cotransfer from a clinical isolate of Shigella flexneri 2a. One of the plasmids, pCN1, was shown by subcloning and DNA sequencing to carry a gene encoding a trimethoprim-insensitive dihydrofolate reductase i...
متن کاملResistance of Haemophilus influenzae to trimethoprim.
Out of 210 isolates of Haemophilus influenzae obtained from the sputum of 63 patients with chronic respiratory infections 109 (52%) were resistant to trimethoprim-sulphamethoxazole by the disc test. The minimal inhibitory concentrations of trimethoprim for 17 out of 18 strains recorded as resistant were 10 mug/ml or higher. Resistant strains were isolated from time to time from 32 (82%) out of ...
متن کاملResistance of Staphylococcus aureus to sulphamethoxazole and trimethoprim.
Strains of Staphylococcus aureus isolated from the lesions of hospital patients were surveyed for resistance to sulphamethoxazole and to trimethoprim. Of 675 strains tested, 18.5% were resistant to sulphamethoxazole and 1.6% to trimethoprim. All the trimethoprim-resistant strains were resistant to sulphamethoxazole and to a 1:20 mixture of the two drugs. Trimethoprim-resistant strains were on a...
متن کاملFactors in the Resistance of Gonorrhea to Sulfonamides.
The problem of resistance to sulfonamide therapy1 in male gonorrhea is well known. Cox (1) states that, in varying degrees, clinical resistance is found in approximately 25 per cent of cases treated with sulfadiazine or sulfathiazole. More recently, the incidence of resistance has risen to approximately 50 per cent of cases admitted to the Boston Dispensary (2). This resistance is manifested ei...
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ژورنال
عنوان ژورنال: Veterinary Research
سال: 2001
ISSN: 0928-4249,1297-9716
DOI: 10.1051/vetres:2001123